Lodging Resident Memory T Cells in the Respiratory Tract as an Approach to Protect Against Influenza Virus Infection

Intranasal delivery of a chitosan-hydrogel vaccine generates nasal tissue resident memory CD8 T cells that are protective against influenza virus infection

JG Bedford, I Caminschi, LM Wakim

2020-12-01

Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we t..

Influenza-specific lung-resident memory t cells are proliferative and polyfunctional and maintain diverse TCR profiles

A Pizzolla, THO Nguyen, S Sant, J Jaffar, T Loudovaris, SI Mannering, PG Thomas, GP Westall, K Kedzierska, LM Wakim

2018-02-01

The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate ..

Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells

A Pizzolla, Z Wang, JR Groom, K Kedzierska, AG Brooks, PC Reading, LM Wakim

2017-05-16

The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL..

Endogenous murine BST-2/tetherin is not a major restriction factor of influenza a virus infection

SL Londrigan, MD Tate, ER Job, JM Moffat, LM Wakim, CA Gonelli, DFJ Purcell, AG Brooks, JA Villadangos, PC Reading, JD Mintern

2015-11-01

BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..

Respiratory DC use IFITM3 to avoid direct viral infection and safeguard virus-specific CD8 T cell priming

G Infusini, JM Smith, H Yuan, A Pizzolla, WC Ng, SL Londrigan, A Haque, PC Reading, JA Villadangos, LM Wakim

2015-11-01

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

2015-09-19

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..